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Thread: branham sign r nicoladonis sign

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    Default branham sign r nicoladonis sign

    what is branham r nicoladonis sign?its significance?

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    Lightbulb Nicoladoni-Branham's sign

    The acute bradycardia induced by the occlusion of an arteriovenous fistula (AVF) is known as the Nicoladoni-Branham sign.This increase in RR interval is mediated by the vagus nerve because it is suppressed by atropine.However, the exact underlying mechanism responsible for this vagal activation is not well understood.It may be that the rise in BP during AVF closure activates the arterial baroreflex and thereby decreases both sympathetic nerve traffic and heart rate.
    In Parkes-Weber syndrome (AV malformation,capillary malformation,congenital varicose veins and skeletal overgrowth).A positive bradycardic reaction (Nicoladoni-Branham sign) portends a poorer prognosis.This test is performed by occluding the arterial inflow by compression with a blood pressure cuff. In a limb with a hemodynamically significant AV malformation, this maneuver leads to reflex bradycardia secondary to a sharp rise in blood pressure. Complications include ulceration and severe lymphedema.
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