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Thread: carneys triad

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    Question carneys triad

    whats carneys triad

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    Quote Originally Posted by bhavana.g View Post
    whats carneys triad

    Carney's Triad
    1. Gastric epithelioid leiomyosarcoma
    2. Functioning extra-adrenal paraganglioma
    3. Pulmonary chondroma.


    In 1977, Carney described the triad.The genetic and pathologic basis of the ssociation is currently unknown. The three constituent entities themselves re relatively unusual, thus the triad is extremely rare. There is an approximately ten-fold female predominance. Due to the rarity of these tumors, the presence of any two of them is regarded as sufficient basis for aking the diagnosis. The time interval between the appearances of the eoplastic lesions can be up to decades, and the tumors can appear in any rder. Once the diagnosis is made, patients must be followed carefully in order to detect new lesions as early as possible, since two of the three entities have malignant potential.

    Gastric leiomyosarcoma is most likely to be present (~97%), followed by pulmonary chondroma (~83%) and paraganglioma ~53%). The complete triad is present in about 33% of cases.
    The overall mortality of the triad is approximately 20%.
    Last edited by dhaval; 12-14-2007 at 04:15 PM.
    Thank you GOD

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    nice dhaval ur obsolutely right can u say all "carney"s in all medical subjects

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    I know about Carney's Complex only...

    Carney's Complex
    Carney complex (CNC) is a familial multiple neoplasia and lentiginosis syndrome. Historically, the complex involved the association of the following conditions:
    (1) Primary pigmented nodular adrenocortical disease (PPNAD), a pituitary independent, primary adrenal form of hypercortisolism;
    (2) Lentigines, ephelides, and blue nevi of the skin and mucosae; and
    (3) A variety of nonendocrine and endocrine tumors.

    The latter include myxomas of the skin, heart, breast, and other sites; psammomatous melanotic schwannoma; growth hormone–producing pituitary adenoma; testicular Sertoli-cell tumor; and, possibly, other benign and malignant neoplasms and conditions, including tumors of the thyroid gland and ductal adenoma of the breast and acromegaly due to somatomammotroph hyperplasia and adenoma not dependent on growth hormone–releasing hormone.

    The pathologic findings of multiple, small, pigmented adrenocortical nodules and internodular cortical atrophy were described as early as 1949 in the adrenal glands of children and young adults with Cushing syndrome.Echocardiograms revealed dense echoes arising from the space between the mitral leaflets; these findings were consistent with the histologic features of a myxoma. Atherton suggested the term nevi, atrial myxoma, myxoid neurofibromas, and ephelides (NAME) syndrome.
    Last edited by dhaval; 12-19-2007 at 07:19 AM.
    Thank you GOD

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