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    Talking difference b/w 2

    what is differnce b/w sickle cell disease and sickle cell triat

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    sickel cell disease is homozygous(SS) form of the illness with the resultant expectant full-blown picture while sickell cell trait is heterozygous(AS) form which never develop any sickel cell related problems except one i.e; painless hematuria
    Last edited by rabia; 07-16-2007 at 01:10 AM.
    Most people are only alive because it is illegal to shoot them.

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    What is sickle cell disease?
    Sickle cell disease is an inherited disorder that affects red blood cells.

    The most common types of sickle cell disease are SS, SC and S beta thalassemia. Other more rare diseases include SD Punjab, SO Arab, S Lepore and SE disease. Sickle cell disease is a lifelong condition that may result in serious health problems. Complications can include painful episodes (crises), anemia (low hemoglobin), organ damage, infections, lung problems, leg ulcers, bone damage and strokes.

    What is sickle cell trait?
    Sickle cell trait is a condition in which there is one gene for the formation of sickle hemoglobin and one for the formation of normal hemoglobin. Sickle cell trait occurs in one out of every 10 African Americans. Usually, people with sickle cell trait do not have any medical problems and they can lead normal lives. They do not develop sickle cell disease.

    Check this PDF file showing nice difference about it.Helpful for 2marks question.

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    u people have give a good discussion but tell me the real clinical importance in which clinician is interested tell me how u people separate the triat from the disease

    because what we need is to prove or disprove the condition by the tests .well
    painless haematuria can occur in several conditions but they can be labelled as triat and also asymptomatic nature of trait ?? how u can they check for triat
    thanx for good discussion
    Last edited by alihussain38; 07-16-2007 at 01:01 AM.

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    Hb electrophoresis is the only confirmatory modality of differentiation. clinically a person with sickel cell trait will never demonstrate vaso-occlusive crisis(nothing suggestive in History or examination), however microscopic hematuria can be the only presentation of persons with this trait.
    Last edited by rabia; 07-16-2007 at 04:42 AM.
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    yes i want to see u people more professional come to the point what u want to see on hb electropherosis that can tell which thing is triat and whcih is diasease !!!

    test all people know but what is the interpretation of that matters for clinician for decision making

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    Interpretation of this test is high at UG level. as i have never seen such tests.but read in the book previously so i can answer.

    Attacks are diagnosed clinically, i.e. there is no gold standard diagnostic test. Haemolysis (causing anaemia and jaundice) is often present, although for painful crises the diagnosis depends essentially on how the patient describes the pain.

    Abnormal hemoglobin forms are detected on hemoglobin electrophoresis, a form of gel electrophoresis on which the various types of hemoglobin move at varying speed.
    Test looks at how hemoglobin moves in an electric field, a process called electrophoresis (ee-LEK-tro-for-EE-sis).
    Sickle-cell hemoglobin (HgbS) and hemoglobin C with sickling (HgbSC)—the two most common forms—can be identified from there. Genetic testing is rarely performed.

    It’s also possible to identify sickle cell anemia before birth. This is done using a sample of amniotic fluid or tissue taken from the placenta. (Amniotic fluid is the fluid in the sac surrounding a growing embryo. The placenta is the organ that attaches the umbilical cord to the mother’s womb.) This test can be done as early as the first few months of pregnancy. It identifies the sickle gene, rather than the hemoglobin it makes.

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    Quote Originally Posted by alihussain38 View Post
    u people have give a good discussion but tell me the real clinical importance in which clinician is interested tell me how u people separate the triat from the disease

    because what we need is to prove or disprove the condition by the tests .well
    painless haematuria can occur in several conditions but they can be labelled as triat and also asymptomatic nature of trait ?? how u can they check for triat
    thanx for good discussion
    Why is it important to know if you have a sickle-cell trait?

    A person inherits genes that produce hemoglobin from his/her parents. It is important to identify people with a hemoglobin trait so they will be aware of their risk of having children with sickle cell disease.

    If one parent has sickle cell trait and the other parent has normal hemoglobin, there is a 50 percent (1 in 2) chance with each pregnancy that the child will be born with sickle cell trait.


    If both parents have sickle cell trait or another hemoglobin trait, there is a 25 percent chance (1 in 4) with each pregnancy that the child will have sickle cell disease.

    -----------
    Medical t/t usually not needed for trait while must for disease.
    advice and precautation to patients with trait that it can be aggravated in certain conditions.
    e.g. patient with polycystic kidney disease can have renal failure if he has sickle-cell trait.

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    If I didn't remember wrongly, trait MAY clinically appear in severe crisis e.g. hypovolemia (ha ha secondary to bleeding in surgery).

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    ya. you are absolutly right.

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