Angina is a chest pain caused due to restriction in blood supply to tissues. In India nicorandil is a vasodilatory drug used to treat angina. The effect of this drug, nicorandil as a vasodilator, is mainly attributed to its nitrate property. In humans, the nitrate action of Nicorandil dilates the large coronary arteries at low plasma concentrations. At high plasma concentrations Nicorandil reduces coronary vascular resistance, which is associated with increased K+ATP channel opening.