Thread: i want to know

Steroid side effects
CUSHINGOID:
Cataracts
Ulcers
Skin: striae, thinning, bruising
Hypertension/ Hirsutism/ Hyperglycemia
Infections
Necrosis, avascular necrosis of the femoral head
Glycosuria
Osteoporosis, obesity
Immunosuppression
Diabetes

how can steriods cause ulcers?
and how steroids increased the neutorphils?

Hi Misha, how are you doing?? Here are your answers:

1. Steroids cause ulcers by increasing gastric acid and pepsin secretion (most probably due to permissive action of steroids on other hormones).

2. Steroids increase neutrophils by an interesting mechanism. Recall that steroids will decrease permeability of endothelium to inflammatory cells at the site of inflammation and thoughout the CVS system in general. As a result less neutrophils will move out of peripheral blood and hence neutrophilia occurs.

I read this from Tripathi a time back. Cheerz..All the best for your exams.