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Thread: Pharmacological classification of drugs

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    Default Pharmacological classification of drugs

    I will post all the classification of diffrent drug groups.

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    5 HT antagonists
    Cyproheptadine
    methysergide
    kentaserin
    clozapine
    risperidone
    ondansetron
    granisetron
    tropisetron

    5 HT agonists
    sumaptriptan,
    almotriptan
    naratriptan
    zolmitriptan
    rizatriptan

    ergot alkaloids
    A. Natural ergot alkaloids - may be considered as derivatives of lysergic acid.
    (a) amine alkaloid - ergometrine (ergonovine) : oxytocic
    (b) amino acid alkaloids - ergotamine, ergotoxine (mixture of ergocristine + ergocornine + ergocryptine) : vasoconstrictor and alpha adrenergic blocker


    B. Other semisynthetic derivatives
    (a) dihydroergotamine (DHE), dihydroergotoxine (codergocrine) : antiadrenergic, cerebroactive
    (b) 2 -bromo-alpha-ergocryptine (bromocriptine) : dopaminergic
    (c) methysergide :anti 5 HT


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    1. Direct sympathomimetics-
    adr, na, isoprenaline, phenylephrine, methoxamine, xylometazoline, salbutamol,etc

    2. Indirect- tyramine

    3. Mixed- ephedrine, amphetamine, mephentermine.





    Therapeutic classification
    1. Pressor agents
    na, phenylephrine, ephedrine, dopamine, methoxamine, mephentermine DEM2NP

    2. Cardiac stimulants
    adr, dobutamine
    isoprenaline ADI

    3. Bronchodilators
    adr, terbutaline, salbutamol(albuterol)
    iso, salmeterol, formoterol

    4. Nasal decong
    phenylephrine, naphazoline
    xylometazoline, pseudoephedrine
    oxymetazoline, phenyl propanolamine

    5. Cns stimulants
    amphetamine, methamphetamine
    dexamphetamine.

    6. Anorectics
    fenfluramine, sibutramine
    dexfenfluramine.

    7. Uterine relaxants & vasodilators
    ritodrine, salbutamol
    isoxsuprine, terbutaline.

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    Alpha Adrenergic Blockers

    1. Nonequiliarium type
    beta haloalkylamines- phenoxybenzamine

    2. Equilibrium type (competitive)
    | nonselective
    a. Ergot alkaloids- ergotamine, ergotoxine
    b. Hydrogenated ergot alkaloids- dihydroergotamine, dihydroergotoxine.
    c. Imidazolines- tolazoline, phentolamine
    d. Miscellaneous- chlorpromazine, ketanserin.

    ||. Alpha-1 selective
    prazosin, terazosin, doxazosin, tamsulosin

    |||. Alpha-2 selective- yohimbine

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    Androgens

    Natural
    Testes - testosterone, dihydrotestosterone
    adrenal cortex - dehydroepiandrosterone, androstenedione (weak androgens)
    testosterone metabolite - androsterone.


    Synthetic androgens
    17-alkyl substituted derivatives of testosterone
    methyltestosterone, fluoxymesterone
    other - testosterone undecanoate, mesterolone.




    Anabolic steroids
    nandrolone, stanozolol, methandienone, oxymetholone.


    Impeded androgens/antiandrogens
    danazol
    cyproterone acetate
    flutamide
    bicalutamide

    5 alpha reductase inhibitor
    finasteride - used in male pattern baldness

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    Antiamoebics

    1. Tissue amoebicides
    (a) for both intestinal & extraintestinal amoebiasis
    nitroimidazoles - metronidazole, tinidazole, secnidazole, ornidazole, satranidazole.
    Alkaloids - emetine, dehydroemetine.
    (b) for extraintestinal amoebiasis only
    chloroquine

    2. Luminal amoebicides
    (a) amide - diloxanide furoate
    (b) 8 hydroxyquinolines - quiniodochlor (iodochlorohydroxyquin, clioquinol), diiodohydroxyquin (iodoquinol)
    (c) antibiotics - tetracyclines.

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    Antianginal Drugs

    1. Nitrates
    (a)short acting- glceryl trinitrate
    (b)long acting- isosorbide dinitrate (short acting by sublingual route), isosorbide mononitrate, erythrityl tetranitrate, penta erythritol tetranitrate.

    2. Beta blockers
    propanolol, metoprolol, atenolol and others.

    3. Calcium channel blockers
    (a)phenyl alkylamine- verapamil
    (b)benzothiazepine- diltiazem
    (c)dihydropyridines- nifedipine, felodipine, amlodipine, nitrendipine, nimodipine, lacidipine.

    4. Potassium channel opener
    nicorandil, pinacidil, cromakalim, minoxidil, diazoxide

    5. Others
    dipyridamole, trimetazidine, oxyphedrine


    clinical classi
    1. To abort or terminate attack
    GTN, isd sublingualy
    2. Chronic prophylaxis- other drugs

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    Anticancer

    Antimetabolites

    1. Folate antagonist
    methotrexate

    2. Purine antagonist
    6-mercaptopurine
    6-thioguanine
    azthioprine

    3. Pyrimidine antagonist
    5-fluorouracil
    cytarabine


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    Anti Cholinergics

    1. Natural alkaloids-atropine, hyoscine (scopolamine)

    2. Semisynthetic derivatives-
    homatropine, atropine methonitrate, hyoscine butyl bromide, ipratropium bromide, tiatropium bromide.

    3. Synthetic compounds
    (a) mydriatics-cyclopentolate, tropicamide.
    (b) antisecretory-spasmodics-
    (1)quaternary compounds-propantheline, oxyphenonium, clidinium, pipenzolate methyl bromide, isopropamide, glycopyrolate.
    (2)tertiary-dicyclomine, oxybutynin, flevoxate, pirenzepine, telenzepine
    (c) antiparkinsonian- trihexyphenidyl, procyclidine, biperiden, benztropine, cycrimine, ethopropazine.












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    AntiCoagulants

    In vitro
    1. Heparin 150 U for 350 ml blood
    2. Calcium complexing agents
    sodium citrate 1.65 g for 350ml
    sodium edetate 2mg for 1ml
    sodium oxalate 10mg for 1ml


    in vivo
    1. Heparin, low molecular weight heparin
    heparinoids - heparan sulfate, ancrod, lepirudin, danaparoid
    2. Oral anticoagulant
    (a)coumarin derivatives
    bishydroxycoumarin (dicumarol)
    warfarin sodium, acenocoumarol (nicoumalone), ethylbiscoumacetate
    (b) indandione derivative
    phenindione




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