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    Thread: Pharmacological classification of drugs

    1. #1
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      Default Pharmacological classification of drugs

      I will post all the classification of diffrent drug groups.

    2. #2
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      5 HT antagonists
      Cyproheptadine
      methysergide
      kentaserin
      clozapine
      risperidone
      ondansetron
      granisetron
      tropisetron

      5 HT agonists
      sumaptriptan,
      almotriptan
      naratriptan
      zolmitriptan
      rizatriptan

      ergot alkaloids
      A. Natural ergot alkaloids - may be considered as derivatives of lysergic acid.
      (a) amine alkaloid - ergometrine (ergonovine) : oxytocic
      (b) amino acid alkaloids - ergotamine, ergotoxine (mixture of ergocristine + ergocornine + ergocryptine) : vasoconstrictor and alpha adrenergic blocker


      B. Other semisynthetic derivatives
      (a) dihydroergotamine (DHE), dihydroergotoxine (codergocrine) : antiadrenergic, cerebroactive
      (b) 2 -bromo-alpha-ergocryptine (bromocriptine) : dopaminergic
      (c) methysergide :anti 5 HT


    3. #3
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      1. Direct sympathomimetics-
      adr, na, isoprenaline, phenylephrine, methoxamine, xylometazoline, salbutamol,etc

      2. Indirect- tyramine

      3. Mixed- ephedrine, amphetamine, mephentermine.





      Therapeutic classification
      1. Pressor agents
      na, phenylephrine, ephedrine, dopamine, methoxamine, mephentermine DEM2NP

      2. Cardiac stimulants
      adr, dobutamine
      isoprenaline ADI

      3. Bronchodilators
      adr, terbutaline, salbutamol(albuterol)
      iso, salmeterol, formoterol

      4. Nasal decong
      phenylephrine, naphazoline
      xylometazoline, pseudoephedrine
      oxymetazoline, phenyl propanolamine

      5. Cns stimulants
      amphetamine, methamphetamine
      dexamphetamine.

      6. Anorectics
      fenfluramine, sibutramine
      dexfenfluramine.

      7. Uterine relaxants & vasodilators
      ritodrine, salbutamol
      isoxsuprine, terbutaline.

    4. #4
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      Alpha Adrenergic Blockers

      1. Nonequiliarium type
      beta haloalkylamines- phenoxybenzamine

      2. Equilibrium type (competitive)
      | nonselective
      a. Ergot alkaloids- ergotamine, ergotoxine
      b. Hydrogenated ergot alkaloids- dihydroergotamine, dihydroergotoxine.
      c. Imidazolines- tolazoline, phentolamine
      d. Miscellaneous- chlorpromazine, ketanserin.

      ||. Alpha-1 selective
      prazosin, terazosin, doxazosin, tamsulosin

      |||. Alpha-2 selective- yohimbine

    5. #5
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      Androgens

      Natural
      Testes - testosterone, dihydrotestosterone
      adrenal cortex - dehydroepiandrosterone, androstenedione (weak androgens)
      testosterone metabolite - androsterone.


      Synthetic androgens
      17-alkyl substituted derivatives of testosterone
      methyltestosterone, fluoxymesterone
      other - testosterone undecanoate, mesterolone.




      Anabolic steroids
      nandrolone, stanozolol, methandienone, oxymetholone.


      Impeded androgens/antiandrogens
      danazol
      cyproterone acetate
      flutamide
      bicalutamide

      5 alpha reductase inhibitor
      finasteride - used in male pattern baldness

    6. #6
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      Antiamoebics

      1. Tissue amoebicides
      (a) for both intestinal & extraintestinal amoebiasis
      nitroimidazoles - metronidazole, tinidazole, secnidazole, ornidazole, satranidazole.
      Alkaloids - emetine, dehydroemetine.
      (b) for extraintestinal amoebiasis only
      chloroquine

      2. Luminal amoebicides
      (a) amide - diloxanide furoate
      (b) 8 hydroxyquinolines - quiniodochlor (iodochlorohydroxyquin, clioquinol), diiodohydroxyquin (iodoquinol)
      (c) antibiotics - tetracyclines.

    7. #7
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      Antianginal Drugs

      1. Nitrates
      (a)short acting- glceryl trinitrate
      (b)long acting- isosorbide dinitrate (short acting by sublingual route), isosorbide mononitrate, erythrityl tetranitrate, penta erythritol tetranitrate.

      2. Beta blockers
      propanolol, metoprolol, atenolol and others.

      3. Calcium channel blockers
      (a)phenyl alkylamine- verapamil
      (b)benzothiazepine- diltiazem
      (c)dihydropyridines- nifedipine, felodipine, amlodipine, nitrendipine, nimodipine, lacidipine.

      4. Potassium channel opener
      nicorandil, pinacidil, cromakalim, minoxidil, diazoxide

      5. Others
      dipyridamole, trimetazidine, oxyphedrine


      clinical classi
      1. To abort or terminate attack
      GTN, isd sublingualy
      2. Chronic prophylaxis- other drugs

    8. #8
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      Anticancer

      Antimetabolites

      1. Folate antagonist
      methotrexate

      2. Purine antagonist
      6-mercaptopurine
      6-thioguanine
      azthioprine

      3. Pyrimidine antagonist
      5-fluorouracil
      cytarabine


    9. #9
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      Anti Cholinergics

      1. Natural alkaloids-atropine, hyoscine (scopolamine)

      2. Semisynthetic derivatives-
      homatropine, atropine methonitrate, hyoscine butyl bromide, ipratropium bromide, tiatropium bromide.

      3. Synthetic compounds
      (a) mydriatics-cyclopentolate, tropicamide.
      (b) antisecretory-spasmodics-
      (1)quaternary compounds-propantheline, oxyphenonium, clidinium, pipenzolate methyl bromide, isopropamide, glycopyrolate.
      (2)tertiary-dicyclomine, oxybutynin, flevoxate, pirenzepine, telenzepine
      (c) antiparkinsonian- trihexyphenidyl, procyclidine, biperiden, benztropine, cycrimine, ethopropazine.












    10. #10
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      AntiCoagulants

      In vitro
      1. Heparin 150 U for 350 ml blood
      2. Calcium complexing agents
      sodium citrate 1.65 g for 350ml
      sodium edetate 2mg for 1ml
      sodium oxalate 10mg for 1ml


      in vivo
      1. Heparin, low molecular weight heparin
      heparinoids - heparan sulfate, ancrod, lepirudin, danaparoid
      2. Oral anticoagulant
      (a)coumarin derivatives
      bishydroxycoumarin (dicumarol)
      warfarin sodium, acenocoumarol (nicoumalone), ethylbiscoumacetate
      (b) indandione derivative
      phenindione




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