Thread: Pharmacological classification of drugs

ANTICHOLINESTERASES


(1) Reversible
carbamates acridine

physostigmine tacrine
neostigmine
pyridostigmine
edrophonium
rivastigmine
donepezil

(2) irreversible
organophosphates carbamates

dyflos carbaryl
ecothiophate propoxur
insect-parapthion
malathion
diazinon
nerve gas-tabun
sarin
soman

Quinolones


Nalidixic acid



first generation fluoroquinolones

norfloxacin
ofloxacin
Ciprofloxacin
Pefloxacin


Second gen

lomefloxacin
Sparfloxacin
levofloxacin
Gatifloxacin
Moxifloxacin

Drugs for Scabies


Permethrin
lindan (BHC gamma benzene hexachloride)
benzyl benzoate
crotamiton
sulfur
dicophane (DDT)
ivermectin

Semisynthetic Penicillins


1. Acid resistant alternative to penicillin G
phenoxymethyl penicillin (penicillin V)
2. Penicillinase resistant penicillins
methicillin, oxacillin, cloxacillin
3. Extended spectrum penicillins
(a) aminopenicillins - ampicillin, bacampicillin, amoxicillin
(b) carboxzpenicillins - carbenicillin, carbenicillin indanyl, carbenicillin phenyl (carfecillin), ticarcillin
(c) ureidopenicillins - piperacillin, mezlocillin
(d) mecillinam (amdinocillin)




beta lactamase inhibitors
clavulanic acid
sulbactam
tazobactam

Skeletal Muscle Relaxants



Peripherally acting
1. neuromuscular blocking agents
A. Non depolarizing (competitive) blockers
(a) long acting- d-tubocurarine, pancuronium, pipecuronium, doxacurium.
(b) intermediate acting - vecuronium, rapacuronium, rocuronium, atracurium, cisatracurium
(c) short acting - mivacurium

B. Depolarising agents
succinylcholine (suxamethonium) (c-10), decamethonium

2. Directly acting agents
quinine, dantrolene sodium.









Centrally acting
1. Mephenesin group
mephenesin, carisoprodol, chlorzoxazone, chlormezanone, methocarbamol.
2. Benzodiazepines
diazepam and others
3. GABA derivative - baclofen
4. Central alpha 2 agonist
tizanidine.

Sulphonemides


1. Short acting
sulfadiazine
2. Intermediate
sulfamethoxazole, sulfamoxole
3. Long
sulfamethopyrazine
4. Special purpose
sulfacetamide sod. , sulfasalazine, mafenide, silver sulfadiazine.

Thyroid Inhibitors


1. Inhibit hormone synthesis (antithyroid drugs)
propylthiouracil, methimazole, carbimazole.

2. Inhibit iodide trapping ( ionic inhibitors)
thiocyanates (-SCN), perchlorates (-CLO4), nitrates (-NO3).

3. Inhibit hormone release
iodine, iodides of na & k, oranic iodide.

4. Destroy thyroid tissue
radioactive iodine ( 131 i, 125 i, 123 i)


1 & 2 are called goitrogens

Uterine Drugs


Uterine stimulants
(oxytocics, ecbolics, abortifacients)
1. Posterior pituitary hormone
oxytocin
2. Ergot alkaloids
ergometrine (ergonovine), methylergometrine
3. Prostaglandins
PGE 2, PGF 2alpha, 15-methyl PGF 2alpha, misoprostol
4. Miscellaneous
ethacridine, quinine



uterine relaxants/tocolytics
1. Adrenergic agonists
ritodrine, salbutamol
isoxsuprine, terbutaline.
2. Magnesium sulfate
3. Ccb
specially nifedipine
4. Prostaglandin synthesis inhibitor
aspirin, ibuprofen, indomethacin
5. Ethyl alcohol
6. Progesterone
7. Miscellaneous
nitrates, diazoxide, atropine, phhenothiazines

Nice try!!Nice to revise too

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