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Thread: Immunology

  1. #1
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    Default Immunology

    haptens

    Haptens are substances which are incapable of inducing antibody formation by themselves but can react specifically with with antibodies.

    Haptens are low-molecular weight molecules which contain an antigenic determinant but which are not itself antigenic unless complexed with an immunogenic carrier.

    Haptens become immunogenic on combining with a larger molecule carrier.

    A well known example of a hapten is urushiol, which is the toxin found in poison ivy.
    Some haptens can induce autoimmune disease. An example is hydralazine, a blood pressure lowering drug which occasionally can produce drug-induced lupus erythematosus in certain individuals.
    This also appears to be the mechanism by which the anaesthetic gas halothane can cause a life-threatening hepatitis, as well as the mechanism by which penicillin-class drugs causes autoimmune hemolytic anemia.


    Haptens can be simple or complex!!
    1. complex haptens...can precipitate with specific antibodies
    2. simple haptens...non precipitating

  2. #2
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    nice oodesh... any thing abot epitopes

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    A hapten is a small molecule that can elicit an immune response only when attached to a large carrier such as a protein; the carrier may be one that also does not elicit an immune response by itself.
    Astermedcity

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    Nice information, immunology is study about the total immune system.

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