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Thread: MCQs: Anti-inflammatory Drugs

  1. #1
    trimurtulu is offline MedicalGeek Resident
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    Arrow MCQs: Anti-inflammatory Drugs

    MCQs: Anti-inflammatory Drugs




    Question # 1 (Multiple Answer) Manifestations of rheumatoid arthritis:

    A) inflammatory synovitis
    B) cartilage destruction
    C) bone erosion
    D) changes in joint integrity
    E) progressive, relentless polyarthritis with functional impairment

    Question # 2 (Multiple Choice) The major role in chronic management of arthritis:

    A) glucocorticoids
    B) nonsteroidal antiinflammatory drugs

    Question # 3 (Multiple Choice) Mechanism of action: aspirin-platelet effects:

    A) promotes platelet aggregation
    B) activates thromboxane synthesis
    C) both
    D) neither

    Question # 4 (Multiple Answer) Factors accounting for rheumatoid arthritis incidence:

    A) genetics
    B) climate
    C) urbanization

    Question # 5 (Multiple Choice) Mediator most likely to promote pain:

    A) histamine
    B) serotonin
    C) bradykinin
    D) prostaglandins
    E) leukotrienes

    Question # 6 (True/False) Aspirin: bleeding time

    A) increases bleeding time
    B) decreases bleeding time

    Question # 7 (True/False) Genetic risk factors fully account for the incidence of rheumatoid arthritis.

    A) true
    B) false

    Question # 8 (Multiple Choice) At low doses required to inhibition of thymidylate synthase, an enhanced adenosine release

    A) chloroquine
    B) gold
    C) methotrexate
    D) cyclophosphamide to
    E) ketorolac

    Question # 9 (Multiple Choice) Mediator promoting greatest increase in vascular permeability, associated with acute inflammation:

    A) serotonin
    B) prostaglandins
    C) bradykinin
    D) leukotrienes

    Question # 10 (Multiple Choice) Isozyme primarily responsible for prostaglandin production by cells involve an inflammation:

    A) COX-I
    B) COX-II

    Question # 11 (Multiple Answer) Aspirin and antipyresis:

    A) elevation of body temperature is typically a useful defense mechanism

    B) aspirin -- best available drug for reducing fever (in the absence of contraindications to its use recurrent

    C) aspirin -- more effective in lowering elevated temperature than normal body temperature

    D) aspirin-induced temperature reduction is caused by vasodilation

    E) fever associated with infection: caused by actions of prostaglandins and interleukin 1 at the periphery


    Question # 12 (Multiple Answer) Phases of inflammation:

    A) acute inflammation
    B) the immune response
    C) chronic inflammation

    Question # 13 (Multiple Answer) Advantages of other NSAIDs compared with aspirin:

    A) generally less expensive
    B) less gastric irritation
    C) potentially better compliance (e.g. naproxen, sulindac)
    D) easier to establish therapeutic range using blood levels
    E) absence of acute renal failure/nephrotic syndrome

    Question # 14 (Multiple Answer) Aspirin:

    A) inhibits prostaglandin synthase
    B) inhibits cyclooxygenase
    C) decreases prostaglandin formation
    D) decreases thromboxane A2 formation
    E) decreases leukotrienes

    Question # 15 (Multiple Answer) Mediators of chronic inflammation in rheumatoid arthritis:

    A) IL-1
    B) IL-2
    C) IL-3
    D) TNF alpha
    E) interferons

    Question # 16 (Multiple Choice) Effective in managing acute gouty arthritisand ankylosing spondylitis; also accelerates closure of patent ductus arteriosus in premature infants:

    A) gold
    B) ketorolac
    C) phenylbutazone
    D) methotrexate
    E) indomethacin

    Question # 17 (Multiple Choice) Approximate prevalence of rheumatoid arthritis:

    A) 1%
    B) 5%
    C) 7%
    D) 10%
    E) 15%

    Question # 18 (Multiple Choice) In rheumatoid arthritis: primary effect of this mediator is on prostaglandin production:

    A) PDGF (platelet-derived growth factor)
    B) GM-CSF
    C) TNF alpha

    Question # 19 (Multiple Choice) Analgesic effects of aspirin:

    A) peripheral action (inflammation)
    B) subcortical site of action
    C) both
    D) neither

    Question # 20 (True/False) rheumatoid arthritis: genetic predisposition

    A) yes
    B) no

    Question # 21 (Multiple Answer) Correct drug-drug interactions:

    A) aspirin -- acetazolamide: enhanced salicylate intoxication
    B) aspirin -- spironolactone: reduced spironolactone activity
    C) aspirin -- probenecid: increased uricosuric activity
    D) aspirin -- phenytoin: increased free phenytoin serum levels
    E) aspirin-alcohol: increased gastrointestinal bleeding

    Question # 22 (Multiple Choice) NSAID primarily promoted as an analgesic, not as an anti-inflammatory agent:

    A) piroxicam
    B) ibuprofen
    C) naproxen
    D) ketorolac
    E) sulindac

    Question # 23 (Multiple Choice) Drug associated with the hepatic/renal toxic metabolite: N-acetyl-p-benzoquinone

    A) diclofenac
    B) meclofenamate
    C) indomethacin
    D) acetaminophen
    E) aspirin


    --------------------------------------------------------------------------


    Correct Answers

    [HIDE]
    Question # 1 (Multiple Answer) Manifestations of rheumatoid arthritis:

    (A) inflammatory synovitis


    (B) cartilage destruction


    (C) bone erosion


    (D) changes in joint integrity


    (E) progressive, relentless polyarthritis with functional impairment



    Question # 2 (Multiple Choice) The major role in chronic management of arthritis:

    Answer: (B) nonsteroidal antiinflammatory drugs



    Question # 3 (Multiple Choice) Mechanism of action: aspirin-platelet effects:

    Answer: (D) neither


    Question # 4 (Multiple Answer) Factors accounting for rheumatoid arthritis incidence:

    (A) genetics


    (B) climate


    (C) urbanization


    Question # 5 (Multiple Choice) Mediator most likely to promote pain:

    Answer: (C) bradykinin


    Question # 6 (True/False) Aspirin: bleeding time

    Answer: True


    Question # 7 (True/False) Genetic risk factors fully account for the incidence of rheumatoid arthritis.

    Answer: False



    Question # 8 (Multiple Choice) At low doses required to inhibition of thymidylate synthase, an enhanced adenosine release

    Answer: (C) methotrexate


    Question # 9 (Multiple Choice) Mediator promoting greatest increase in vascular permeability, associated with acute inflammation:

    Answer: (D) leukotrienes


    Question # 10 (Multiple Choice) Isozyme primarily responsible for prostaglandin production by cells involve an inflammation:

    Answer: (B) COX-II


    Question # 11 (Multiple Answer) Aspirin and antipyresis:

    (B) aspirin -- best available drug for reducing fever (in the absence of contraindications to its use recurrent


    (C) aspirin -- more effective in lowering elevated temperature than normal body temperature


    (D) aspirin-induced temperature reduction is caused by vasodilation



    Question # 12 (Multiple Answer) Phases of inflammation:

    (A) acute inflammation


    (B) the immune response


    (C) chronic inflammation



    Question # 13 (Multiple Answer) Advantages of other NSAIDs compared with aspirin:

    (B) less gastric irritation


    (C) potentially better compliance (e.g. naproxen, sulindac)



    Question # 14 (Multiple Answer) Aspirin:

    (A) inhibits prostaglandin synthase


    (B) inhibits cyclooxygenase


    (C) decreases prostaglandin formation


    (D) decreases thromboxane A2 formation


    Question # 15 (Multiple Answer) Mediators of chronic inflammation in rheumatoid arthritis:

    (A) IL-1


    (B) IL-2


    (C) IL-3


    (D) TNF alpha


    (E) interferons


    Question # 16 (Multiple Choice) Effective in managing acute gouty arthritisand ankylosing spondylitis; also accelerates closure of patent ductus arteriosus in premature infants:

    Answer: (E) indomethacin


    Question # 17 (Multiple Choice) Approximate prevalence of rheumatoid arthritis:

    Answer: (A) 1%


    Question # 18 (Multiple Choice) In rheumatoid arthritis: primary effect of this mediator is on prostaglandin production:

    Answer: (C) TNF alpha



    Question # 19 (Multiple Choice) Analgesic effects of aspirin:

    Answer: (C) both


    Question # 20 (True/False) rheumatoid arthritis: genetic predisposition

    Answer: True


    Question # 21 (Multiple Answer) Correct drug-drug interactions:

    (A) aspirin -- acetazolamide: enhanced salicylate intoxication


    (B) aspirin -- spironolactone: reduced spironolactone activity


    (D) aspirin -- phenytoin: increased free phenytoin serum levels


    Question # 22 (Multiple Choice) NSAID primarily promoted as an analgesic, not as an anti-inflammatory agent:

    Answer: (D) ketorolac


    Question # 23 (Multiple Choice) Drug associated with the hepatic/renal toxic metabolite: N-acetyl-p-benzoquinone

    Answer: (D) acetaminophen

    [/HIDE]


    .

  2. #2
    Alhout is offline MedicalGeek Verified
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    geilkaushik is offline MedicalGeek Verified
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    sushilpawar007 is offline MedicalGeek Verified
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