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Thread: MCQs: Anti-Malarials

  1. #1
    trimurtulu is offline MedicalGeek Resident
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    Arrow MCQs: Anti-Malarials

    MCQs: Anti-Malarials



    Question # 1 (Multiple Answer) Antimalarials: dihydrofolate reductase inhibitors

    A) chloroquine (Aralen)
    B) chloroguanide
    C) pyrimethamine (Daraprim)
    D) trimethoprim (generic)
    E) primaquine

    Question # 2 (Multiple Answer) Characteristics of significant parasitization, i.e. P falciparum:

    A) vasoconstriction
    B) hemoglobinuria
    C) microthrombi formation
    D) if > 20% of erythrocytes are parasitized, mortality = 50% (P falciparum)

    Question # 3 (Multiple Answer) One cycle of liver invasion and multiplication:

    A) P vivax
    B) P falciparum
    C) P. malariae
    D) P ovale

    Question # 4 (Multiple Choice) Factors which determine antimalarial agent efficacy:

    A) species
    B) life-cycle stage-dependencies
    C) both
    D) neither

    Question # 5 (Multiple Choice) Asserting a malarial diagnosis:

    A) fever/flu-like symptoms in individual returning from travel (or native to) a malarious geographical region
    B) disease ruled out the patient has taken prophylactic drugs during travel
    C) both
    D) neither

    Question # 6 (Multiple Answer) Malaria prophylaxis:for regions with chloroquine (Aralen)-resistant P falciparum malaria

    A) preferred: mefloquine (Lariam)
    B) alternative #1:doxycycline (Vibramycin, Doryx)
    C) alternative #2: chloroquine (Aralen) plus proguanil (Paludrine)

    Question # 7 (Multiple Answer) Malaria: etiology --

    A) only arthropod vector-byte to the female anopheline mosquito
    B) transmission does not occur at < 60 degrees Fahrenheit or at >100 degrees Fahrenheit
    C) incubation period: typically three-four weeks

    Question # 8 (Multiple Answer) Antimalarials: classification based on site of drug action:

    A) gametocides
    B) tissue schizonticides
    C) blood schizonticides, e.g. chloroquine (Aralen), proguanil (Paludrine), pyrimethamine (Daraprim), mefloquine (Lariam), quinine (Quinamm)
    D) gametocides: primaquine (P falciparum; chloroquine (Aralen) (P vivax, P. malariae, P ovale)

    Question # 9 (Multiple Answer) Treatment of malaria-all species except chloroquine (Aralen)-resistant P falciparum

    A) Oral treatment (P falciparum or P. malariae): chloroquine phosphate (Aralen)

    B) Oral treatment (P vivax or P ovale): chloroquine (Aralen) plus primaquine phosphate

    C) Parenteral treatment (severe attacks): quinidine gluconate (Quinaglute, Quinalan) followed by oral chloroquine (Aralen) when possible {followed by primaquine if infection is caused by P vivax or P ovalea brace

    Question # 10 (Multiple Answer) Malaria: objective clinical presentations

    A) orthostatic hypotension
    B) faint scleral icterus
    C) meningismus
    D) during paroxysmal phase: high fever (up to 106 degrees Fahrenheit)

    Question # 11 (Multiple Answer) Malaria:

    A) about one million deaths per year due to malaria
    B) most important parasitic infection
    C) most U.S. cases found in transfusion recipients and intravenous drug users
    D) increase in incidence secondary to increasing drug- resistance to P falciparum & failure of mosquito eradication programs

    Question # 12 (Multiple Answer) Major malarial symptoms:

    A) cold phase-patient complains of chills
    B) hot phase-associated with high fever, headache, vomiting, nausea, delirium
    C) defervescence;profuse sweating and sleep
    D) none of the above

    Question # 13 (True/False) Treatment of malaria caused by chloroquine (Aralen)-resistant P falciparumral:quinine sulfate and clindamycin (Cleocin)

    A) True
    B) False

    Question # 14 (Multiple Answer) Treatment must eliminate parasites from both liver and erythrocytes:

    A) P falciparum
    B) P. malariae
    C) P vivax
    D) P ovale

    Question # 15 (Multiple Choice) Of the plasmodium species causative for human malaria, the one producing most serious complications:

    A) Plasmodium vivax
    B) Plasmodium malariae
    C) Plasmodium ovale
    D) plasmodium falciparum

    Question # 16 (Multiple Answer) Concerning definitive malaria diagnosis:

    A) if thin blood smear is negative, examine thick smear {may be positive than 20%-25% of patients}
    B) examination of blood smear should be done once approximately seven days after initial visit
    C) a critical factor is to determine if patient has falciparum malaria which may be fatal due to high-rate of erythrocyte parasitization


    -------------------------------------------


    Correct Answers

    [HIDE]
    Question # 1 (Multiple Answer) Antimalarials: dihydrofolate reductase inhibitors

    (B) chloroguanide


    (C) pyrimethamine (Daraprim)


    (D) trimethoprim (generic)


    Question # 2 (Multiple Answer) Characteristics of significant parasitization, i.e. P falciparum:

    (B) hemoglobinuria


    (C) microthrombi formation


    (D) if > 20% of erythrocytes are parasitized, mortality = 50% (P falciparum)


    vasodilation



    Question # 3 (Multiple Answer) One cycle of liver invasion and multiplication:

    (B) P falciparum


    (C) P. malariae



    Question # 4 (Multiple Choice) Factors which determine antimalarial agent efficacy:

    Answer: (C) both


    Question # 5
    (Multiple Choice) Asserting a malarial diagnosis:

    Answer: (A) fever/flu-like symptoms in individual returning from travel (or native to) a malarious geographical region


    Question # 6 (Multiple Answer) Malaria prophylaxis:for regions with chloroquine (Aralen)-resistant P falciparum malaria

    (A) preferred: mefloquine (Lariam)


    (B) alternative #1:doxycycline (Vibramycin, Doryx)


    (C) alternative #2: chloroquine (Aralen) plus proguanil (Paludrine)


    Question # 7 (Multiple Answer) Malaria: etiology --

    (A) only arthropod vector-byte to the female anopheline mosquito


    (B) transmission does not occur at < 60 degrees Fahrenheit or at >100 degrees Fahrenheit


    incubation period: 8-10 days



    Question # 8 (Multiple Answer) Antimalarials: classification based on site of drug action:

    (A) gametocides


    (B) tissue schizonticides


    (C) blood schizonticides, e.g. chloroquine (Aralen), proguanil (Paludrine), pyrimethamine (Daraprim), mefloquine (Lariam), quinine (Quinamm)


    (D) gametocides: primaquine (P falciparum; chloroquine (Aralen) (P vivax, P. malariae, P ovale)


    Question # 9 (Multiple Answer) Treatment of malaria-all species except chloroquine (Aralen)-resistant P falciparum

    (A) Oral treatment (P falciparum or P. malariae): chloroquine phosphate (Aralen)


    (B) Oral treatment (P vivax or P ovale): chloroquine (Aralen) plus primaquine phosphate


    (C) Parenteral treatment (severe attacks): quinidine gluconate (Quinaglute, Quinalan) followed by oral chloroquine (Aralen) when possible {followed by primaquine if infection is caused by P vivax or P ovalea brace


    Question # 10 (Multiple Answer) Malaria: objective clinical presentations

    (A) orthostatic hypotension


    (B) faint scleral icterus


    (C) meningismus


    (D) during paroxysmal phase: high fever (up to 106 degrees Fahrenheit)


    Question # 11 (Multiple Answer) Malaria:

    (A) about one million deaths per year due to malaria


    (B) most important parasitic infection


    (D) increase in incidence secondary to increasing drug- resistance to P falciparum & failure of mosquito eradication programs


    most U.S. cases found in travelers



    Question # 12 (Multiple Answer) Major malarial symptoms:

    (A) cold phase-patient complains of chills


    (B) hot phase-associated with high fever, headache, vomiting, nausea, delirium


    (C) defervescence;profuse sweating and sleep



    Question # 13 (True/False) Treatment of malaria caused by chloroquine (Aralen)-resistant P falciparumral:quinine sulfate and clindamycin (Cleocin)

    Answer: True


    Question # 14 (Multiple Answer) Treatment must eliminate parasites from both liver and erythrocytes:

    (C) P vivax


    (D) P ovale


    Question # 15 (Multiple Choice) Of the plasmodium species causative for human malaria, the one producing most serious complications:

    Answer: (D) plasmodium falciparum


    Question # 16 (Multiple Answer) Concerning definitive malaria diagnosis:

    (A) if thin blood smear is negative, examine thick smear {may be positive than 20%-25% of patients}


    (C) a critical factor is to determine if patient has falciparum malaria which may be fatal due to high-rate of erythrocyte parasitization

    blood smear examinations required at intervals over several days

    [/HIDE]

  2. #2
    trimurtulu is offline MedicalGeek Resident
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    Question # 1 (Multiple Answer) Chloroquine (Aralen) pharmacology:

    A) effective against gametocytes of P falciparum
    B) used to treat P vivax, P ovale, P. malariae attacks
    C) both
    D) neither

    Question # 2 (Multiple Choice) chloroquine (Aralen) contraindications:

    A) patients with retinal/visual field abnormalities
    B) in patients predisposed to porphyria
    C) both
    D) neither

    Question # 3 (Multiple Answer) Clinical uses: chloroquine (Aralen)-

    A) amebiasis
    B) malaria prophylaxis
    C) acute malarial attacks
    D) autoimmune disease

    Question # 4 (Multiple Answer) Mefloquine (Lariam) antimalarial properties:

    A) active against P falciparum gametocytes
    B) blood schizonticidal activity against P falciparum & P vivax
    C) inactive against hepatic stages of P vivax

    Question # 5 (Multiple Answer) Contraindication(s): mefloquine (Lariam)-

    A) epilepsy
    B) cardiac conduction anomalies
    C) psychiatric disturbance

    Question # 6 (Multiple Answer) Antimalarial property/properties: primaquine --

    A) active against late hepatic stages
    B) active against primary exoerythrocytic P falciparum stage
    C) prophylaxis with chloroquine (Aralen) against P ovale
    D) highly gametocidal against P vivax

    Question # 7 (Multiple Choice) Clinical uses: primaquine

    A) treatment of Pneumocystis carinii pneumonia
    B) radical cure of acute P ovale malaria
    C) both
    D) neither

    Question # 8 (Multiple Choice) Clinical uses: chloroguanide

    A) malarial chemoprophylaxis
    B) Toxoplasmosis
    C) both
    D) neither

    Question # 9 (Multiple Answer) Characteristics of quinine (Quinamm) antimalarial activity:

    A) slow onset
    B) poorly effective blood schizonticide against P vivax
    C) gametocidal for P ovale

    Question # 10 (Multiple Answer) Adverse effects-quinine (Quinamm):

    A) epigastric pain
    B) cinchonism
    C) hypoglycemia
    D) paresthesias
    E) temporal arteritis


    --------------------------------------------------------------------------


    Correct Answers


    [HIDE]
    Question # 1 (Multiple Answer) Chloroquine (Aralen) pharmacology:

    (B) used to treat P vivax, P ovale, P. malariae attacks


    Question # 2 (Multiple Choice) chloroquine (Aralen) contraindications:

    Answer: (C) both


    Question # 3 (Multiple Answer) Clinical uses: chloroquine (Aralen)-

    (A) amebiasis


    (B) malaria prophylaxis


    (C) acute malarial attacks


    (D) autoimmune disease


    Question # 4 (Multiple Answer) Mefloquine (Lariam) antimalarial properties:

    (B) blood schizonticidal activity against P falciparum & P vivax


    (C) inactive against hepatic stages of P vivax



    Question # 5 (Multiple Answer) Contraindication(s): mefloquine (Lariam)-

    (A) epilepsy


    (B) cardiac conduction anomalies


    (C) psychiatric disturbance


    Question # 6 (Multiple Answer) Antimalarial property/properties: primaquine --

    (A) active against late hepatic stages


    (B) active against primary exoerythrocytic P falciparum stage


    (C) prophylaxis with chloroquine (Aralen) against P ovale


    (D) highly gametocidal against P vivax


    Question # 7 (Multiple Choice) Clinical uses: primaquine

    Answer: (C) both


    Question # 8 (Multiple Choice) Clinical uses: chloroguanide

    Answer: (C) both


    Question # 9 (Multiple Answer) Characteristics of quinine (Quinamm) antimalarial activity:

    (C) gametocidal for P ovale


    Question # 10 (Multiple Answer) Adverse effects-quinine (Quinamm):

    (A) epigastric pain


    (B) cinchonism


    (C) hypoglycemia

    [/HIDE]


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