Thread: MCQs : Autacoids

Autacoids

Question # 1 (Multiple Answer) CNS serotonin:

A) mood
B) sleep
C) appetite
D) pain perception
E) vomiting

Question # 2 (True/False) Propofol (Diprivan) for induction and maintenance of anesthesia may be as effective as ondansetron (Zofran) in reducing/preventing postoperative emesis

A) true
B) false

Question # 3 (Multiple Choice) Serotonin overproduction (carcinoid tumor):

A) constipation
B) diarrhea

Question # 4 (Multiple Choice) Major clinical use(s): cyproheptadine (Periactin):

A) reduces smooth muscle effects of carcinoid tumor
B) reduces postgastrectomy dumping syndrome
C) both
D) neither

Question # 5 (Multiple Choice) Widely distributed indoleethylamine formed from tryptophan:

A) epinephrine
B) nicotine
C) serotonin
D) leukotriene
E) prostaglandins

Question # 6 (True/False) Serotonin -- gastrointestinal tract effects:decreased peristalsis

A) true
B) false

Question # 7 (Multiple Choice) Antiemetic agent with least side effects

A) chlorpromazine (Thorazine)
B) butyrophenones
C) ondansetron (Zofran)
D) diphenhydramine (Benadryl)

Question # 8 (Multiple Choice) Serotonin: platelet effects --

A) promotes aggregation
B) inhibits aggregation

Question # 9 (Multiple Choice) Greater than 90% of serotonin is located here:

A) platelets
B) raphe nucleus (brain stem)
C) enterochromaffin cells of the GI tract
D) lung
E) cerebral cortex

Question # 10 (Multiple Answer) Cardiovascular effects of serotonin:

A) skeletal muscle vasculature: vasodilatation
B) reflex bradycardia
C) pulmonary and renal vasculature: vasoconstriction

Question # 11 (Multiple Answer) Sumatriptan (Imitrex) and migraine:

A) relieves symptoms for few patients
B) efficacy greater than or equal to other drug treatments
C) multiple dosing may be required

Question # 12 (Multiple Answer) Serotonin agonists -- clinical use:

A) buspirone -- anxiolytic
B) sumatriptan (Imitrex) -- antimigraine; anti-cluster headaches
C) both
D) neither

Question # 13 (Multiple Answer) Serotonin: nervous system --

A) stimulates itch and pain sensory nerve endings
B) activates chemosensitive nerve endings in coronary vessels
C) atropine-sensitive bradycardia
D) activates medullary vomiting reflex (5 HT3)

Question # 14 (Multiple Choice) ondansetron (Zofran), granisetron (Kytril), tropisetron interact with its serotonin receptor subtype located in the area postrema, sensory, and enteric nerves:

A) 5 HT1a
B) 5 HT1d
C) 5 HT3
D) 5 HT4

Question # 15 (Multiple Choice) Sumatriptan (Imitrex) -- contraindications

A) presence of ischemic heart disease
B) patients have variant (Prinzmetal's) angina
C) both
D) neither

Question # 16 (Multiple Answer) Ondansetron (Zofran) -- pharmacology:

A) activates dopamine (Intropin), histamine and adrenergic receptors
B) very effective for prevention of nausea iand vomiting caused by chemotherapy or surgery
C) reduces postoperative vomiting in patients following middle ear surgery

Question # 17 (Multiple Answer) Adverse effects -- sumatriptan (Imitrex)

A) muscle weakness
B) chest pain
C) dizziness
D) altered sensations (tingling, warmth recurrent


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Correct Answers

[HIDE]
Question # 1 (Multiple Answer) CNS serotonin:

(A) mood


(B) sleep


(C) appetite


(D) pain perception


(E) vomiting



Question # 2 (True/False) Propofol (Diprivan) for induction and maintenance of anesthesia may be as effective as ondansetron (Zofran) in reducing/preventing postoperative emesis

Answer: True


Question # 3 (Multiple Choice) Serotonin overproduction (carcinoid tumor):

Answer: (B) diarrhea


Question # 4 (Multiple Choice) Major clinical use(s): cyproheptadine (Periactin):

Answer: (C) both


Question # 5 (Multiple Choice) Widely distributed indoleethylamine formed from tryptophan:

Answer: (C) serotonin



Question # 6 (True/False) Serotonin -- gastrointestinal tract effects:decreased peristalsis

Answer: False


Question # 7 (Multiple Choice) Antiemetic agent with least side effects

Answer: (C) ondansetron (Zofran)


Question # 8 (Multiple Choice) Serotonin: platelet effects --

Answer: (A) promotes aggregation


Question # 9 (Multiple Choice) Greater than 90% of serotonin is located here:

Answer: (C) enterochromaffin cells of the GI tract


Question # 10 (Multiple Answer) Cardiovascular effects of serotonin:

(A) skeletal muscle vasculature: vasodilatation


(B) reflex bradycardia


(C) pulmonary and renal vasculature: vasoconstriction


Question # 11 (Multiple Answer) Sumatriptan (Imitrex) and migraine:

(B) efficacy greater than or equal to other drug treatments


(C) multiple dosing may be required


Question # 12 (Multiple Answer) Serotonin agonists -- clinical use:

(C) both


Question # 13 (Multiple Answer) Serotonin: nervous system --

(A) stimulates itch and pain sensory nerve endings


(B) activates chemosensitive nerve endings in coronary vessels


(C) atropine-sensitive bradycardia


(D) activates medullary vomiting reflex (5 HT3)


Question # 14 (Multiple Choice) ondansetron (Zofran), granisetron (Kytril), tropisetron interact with its serotonin receptor subtype located in the area postrema, sensory, and enteric nerves:

Answer: (C) 5 HT3


Question # 15 (Multiple Choice) Sumatriptan (Imitrex) -- contraindications

Answer: (C) both


Question # 16 (Multiple Answer) Ondansetron (Zofran) -- pharmacology:

(B) very effective for prevention of nausea iand vomiting caused by chemotherapy or surgery


(C) reduces postoperative vomiting in patients following middle ear surgery


Question # 17 (Multiple Answer) Adverse effects -- sumatriptan (Imitrex)

(A) muscle weakness


(B) chest pain


(C) dizziness


(D) altered sensations (tingling, warmth recurrent
[/HIDE]







.

Question # 1 (True/False) Uterine sensitivity to ergot alkaloids increases as pregnancy progresses:

A) true
B) false

Question # 2 (Multiple Answer) Migraine: clinical presentations/characteristics

A) usually unilaterall headache
B) associated with stress
C) equally common in women and men
D) may be accompanied by a brief aura

Question # 3 (Multiple Choice) Vasoconstriction-- bradykinin

A) arteriolar vascularl smooth muscle
B) venular smooth muscle

Question # 4 (Multiple Choice) Less sedating:

A) diphenhydramine (Benadryl)
B) terfenadine (Seldane)
C) about equal

Question # 5 (Multiple Choice) Most uterine selective -- agent of choice for obstetric use among ergot alkaloids

A) ergotamine
B) ergonovine
C) methysergide (Sansert)

Question # 6 (Multiple Answer) Histamine receptor sites-- H1

A) endothelium
B) smooth muscle
C) mast cell
D) gastric mucosa

Question # 7 (Multiple Choice) More likely to be effective in treating an active migraine attack:

A) sumatriptan (Imitrex)
B) methysergide (Sansert)
C) equally effective

Question # 8 (Multiple Choice) Drug treatment for hyperprolactinemia:

A) bromocriptine (Parlodel)
B) pergolide (Permax)
C) both
D) either

Question # 9 (True/False) Long-lasting vasospasm caused by ergotamine overdosage is reversible by alpha antagonists or serotonin antagonists:

A) true
B) false

Question # 10 (Multiple Choice) Ergot alkaloid -- antimigraine specificity mediated by these receptors:

A) adrenergic
B) cholinergic
C) serotonergic
D) dopaminergic

Question # 11 (Multiple Choice) Losartin (Cozaar): higher affinity for

A) AT1 angiotensin receptors
B) AT2 angiotensin receptors

Question # 12 (Multiple Choice) Enzyme catalyzing conversion of angiotensinogen to angiotensin I:

A) serum cholinesterase
B) aspartyl protease
C) dopamine beta-hydroxylase
D) phenylethanolamine N-methyltransferase

Question # 13 (True/False) Migraine -- drug treatment: alternative to ergotamine for acute migraine treatment but not recommended for patients with coronary vascular disease-- sumatriptan (Imitrex)

A) true
B) false

Question # 14 (Multiple Choice) Synthesis site of most circulatory renin:

A) pulmonary
B) liver
C) kidney
D) brain
E) platelet

Question # 15 (True/False) Angiotensin II effects may cause vascular and myocardial hypertrophy

A) true
B) false

Question # 16 (Multiple Choice) CNS effects of ergot alkaloids:

A) activation of pituitary prolactin secretion
B) hallucinogenic effects
C) both
D) either

Question # 17 (Multiple Answer) Mechanism(s) of action for angiotensin II vasopressor response:

A) CNS mediated
B) ANS mediated
C) direct arteriolar smooth muscle contraction

Question # 18 (True/False) Angiotensin II is a more potent vasopressor than norepinephrine

A) true
B) false

Question # 19 (Multiple Choice) Most commonly used drug for continuous migraine prophylaxis:

A) methysergide (Sansert)
B) ergonovine
C) propranolol (Inderal)
D) amitriptyline (Elavil, Endep)
E) valproic acid

Question # 20 (Multiple Choice) Most common acute ergot toxicity:

A) vasospasm
B) retroperitoneal fibroplasia
C) gastrointestinal upset -- e.g. vomiting
D) subendocardial fibrosis

Question # 21 (Multiple Answer) Receptors affected by ergot alkaloids

A) alpha-adrenergic
B) dopamine receptors
C) serotonin receptors

Question # 22 (Multiple Choice) Equal affinity for saralasin and angiotensin II:

A) AT1 -type angiotensin receptor
B) AT2 -type angiotensin receptor

Question # 23 (Multiple Answer) Sites of angiotensin II actions:

A) vascular smooth muscle
B) brain
C) adrenal cortex
D) kidney

Question # 24 (Multiple Choice) Reverses serious ergot alkaloid-mediated vasospastic reactions:

A) nitroglycerin
B) nitroprusside sodium (Nipride)
C) both
D) neither

Question # 25 (True/False) Major plasma kinin: bradykinin

A) true
B) false

Question # 26 (Multiple Answer) Likely to block renin secretion:

A) clonidine (Catapres)
B) isoproterenol
C) methyldopa (Aldomet)
D) metoprolol (Lopressor)

Question # 27 (Multiple Choice) Receptor type mediating urinary retention associated with first-generation H1 antagonists:

A) adrenergic
B) cholinergic
C) serotonergic
D) GABA-ergic

Question # 28 (Multiple Answer) Stimulates renin-angiotensin system:

A) hydralazine (Apresoline)
B) isoproterenol
C) diuretics
D) losartin (Cozaar)

Question # 29 (Multiple Choice) Common side effect of first-generation H1 antagonists:

A) tachycardia
B) pulmonary hypertension
C) cholecystitis
D) sedation
E) intraperitoneal fibroplasia

Question # 30 (Multiple Choice) Fewer drug-drug interactions

A) terfenadine (Seldane)
B) fexofenadine (Allegra)
C) about equal

Question # 31 (Multiple Answer) Associated with ergotamine -- drug treatment for migraine:

A) best results obtained after attack begins
B) ergotamine commonly combined with caffeine; caffeine promotes ergot alkaloid absorption
C) excessive ergotamine may cause long-lasting, severe vasoconstriction

Question # 32 (True/False) Used to control late uterine bleeding,ergot derivatives are given before delivery

A) true
B) false

Question # 33 (Multiple Answer) clinical uses: H2 receptor blockade:

A) peptic ulcer duodenal disease
B) gastric ulcer
C) gastroesophageal reflux disorder (erosive esophagitis)
D) Zollinger-Ellison disease

Question # 34 (Multiple Choice) Angiotensin antagonist(s):

A) losartin (Cozaar)
B) valsartan (Diovan)
C) both
D) neither

Question # 35 (Multiple Choice) Vascular smooth muscle effects --ergotamine:

A) vasodilatation
B) vasoconstriction

Question # 36 (Multiple Choice) Cardiotoxicity in combining terfenadine (Seldane) with ketoconazole (Nizoral),

A) characterized by Q-T (ECG) prolongation
B) may cause ventricular arrhythmias; potentially fatal
C) both
D) either

Question # 37 (Multiple Answer) Effects of angiotensin II on the kidney:

A) renovascular dilation
B) enhanced sodium reabsorption at the proximal tubule
C) renin secretion


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Correct Answers


[HIDE]
Question # 1 (True/False) Uterine sensitivity to ergot alkaloids increases as pregnancy progresses:

Answer: True


Question # 2 (Multiple Answer) Migraine: clinical presentations/characteristics

(A) usually unilaterall headache


(B) associated with stress


(D) may be accompanied by a brief aura



Question # 3 (Multiple Choice) Vasoconstriction-- bradykinin

Answer: (B) venular smooth muscle


Question # 4 (Multiple Choice) Less sedating:

Answer: (B) terfenadine (Seldane)


Question # 5 (Multiple Choice) Most uterine selective -- agent of choice for obstetric use among ergot alkaloids

Answer: (B) ergonovine


Question # 6 (Multiple Answer) Histamine receptor sites-- H1

(A) endothelium


(B) smooth muscle


Question # 7 (Multiple Choice) More likely to be effective in treating an active migraine attack:

Answer: (A) sumatriptan (Imitrex)



Question # 8 (Multiple Choice) Drug treatment for hyperprolactinemia:

Answer: (C) both


Question # 9 (True/False) Long-lasting vasospasm caused by ergotamine overdosage is reversible by alpha antagonists or serotonin antagonists:

Answer: False



Question # 10 (Multiple Choice) Ergot alkaloid -- antimigraine specificity mediated by these receptors:

Answer: (C) serotonergic


Question # 11 (Multiple Choice) Losartin (Cozaar): higher affinity for

Answer: (A) AT1 angiotensin receptors


Question # 12 (Multiple Choice) Enzyme catalyzing conversion of angiotensinogen to angiotensin I:

Answer: (B) aspartyl protease


Question # 13 (True/False) Migraine -- drug treatment: alternative to ergotamine for acute migraine treatment but not recommended for patients with coronary vascular disease-- sumatriptan (Imitrex)

Answer: True


Question # 14 (Multiple Choice) Synthesis site of most circulatory renin:

Answer: (C) kidney


Question # 15 (True/False) Angiotensin II effects may cause vascular and myocardial hypertrophy

Answer: True


Question # 16 (Multiple Choice) CNS effects of ergot alkaloids:

Answer: (B) hallucinogenic effects


Question # 17 (Multiple Answer) Mechanism(s) of action for angiotensin II vasopressor response:

(A) CNS mediated


(B) ANS mediated


(C) direct arteriolar smooth muscle contraction




Question # 18 (True/False) Angiotensin II is a more potent vasopressor than norepinephrine

Answer: True


Question # 19 (Multiple Choice) Most commonly used drug for continuous migraine prophylaxis:

Answer: (C) propranolol (Inderal)


Question # 20 (Multiple Choice) Most common acute ergot toxicity:

Answer: (C) gastrointestinal upset -- e.g. vomiting


Question # 21 (Multiple Answer) Receptors affected by ergot alkaloids

(A) alpha-adrenergic


(B) dopamine receptors


(C) serotonin receptors



Question # 22 (Multiple Choice) Equal affinity for saralasin and angiotensin II:

Answer: (B) AT2 -type angiotensin receptor


Question # 23 (Multiple Answer) Sites of angiotensin II actions:

(A) vascular smooth muscle


(B) brain


(C) adrenal cortex


(D) kidney


Question # 24 (Multiple Choice) Reverses serious ergot alkaloid-mediated vasospastic reactions:

Answer: (C) both


Question # 25 (True/False) Major plasma kinin: bradykinin

Answer: True


Question # 26 (Multiple Answer) Likely to block renin secretion:

(A) clonidine (Catapres)


(C) methyldopa (Aldomet)


(D) metoprolol (Lopressor)



Question # 27 (Multiple Choice) Receptor type mediating urinary retention associated with first-generation H1 antagonists:

Answer: (B) cholinergic


Question # 28 (Multiple Answer) Stimulates renin-angiotensin system:

(A) hydralazine (Apresoline)


(B) isoproterenol


(C) diuretics



Question # 29 (Multiple Choice) Common side effect of first-generation H1 antagonists:

Answer: (D) sedation



Question # 30 (Multiple Choice) Fewer drug-drug interactions

Answer: (B) fexofenadine (Allegra)


Question # 31 (Multiple Answer) Associated with ergotamine -- drug treatment for migraine:

(B) ergotamine commonly combined with caffeine; caffeine promotes ergot alkaloid absorption


(C) excessive ergotamine may cause long-lasting, severe vasoconstriction[/HIDE]

Originally Posted by trimurtulu

Autacoids

Question # 1 (Multiple Answer) CNS serotonin:

A) mood
B) sleep
C) appetite
D) pain perception
E) vomiting

Question # 2 (/False) Propofol (Diprivan) for induction and maintenance of anesthesia may be as effective as () in reducing/preventing postoperative emesis

A)
B) false

Question # 3 (Multiple Choice) Serotonin overproduction (carcinoid tumor):

A) constipation
B)

Question # 4 (Multiple Choice) Major use(s): ():

A) reduces smooth muscle effects of carcinoid tumor
B) reduces postgastrectomy dumping syndrome
C) both
D) neither

Question # 5 (Multiple Choice) Widely distributed indoleethylamine formed from tryptophan:

A) epinephrine
B) nicotine
C) serotonin
D) leukotriene
E) prostaglandins

Question # 6 (True/False) Serotonin -- tract effects:decreased peristalsis

A) true
B) false

Question # 7 (Multiple Choice) Antiemetic agent with least side effects

A) ()
B) butyrophenones
C) ondansetron (Zofran)
D) diphenhydramine (Benadryl)

Question # 8 (Multiple Choice) Serotonin: platelet effects --

A) promotes aggregation
B) inhibits aggregation

Question # 9 (Multiple Choice) Greater than 90% of serotonin is located here:

A) platelets
B) raphe nucleus (brain stem)
C) enterochromaffin cells of the GI tract
D) lung
E) cerebral cortex

Question # 10 (Multiple Answer) Cardiovascular effects of serotonin:

A) vasculature: vasodilatation
B) reflex bradycardia
C) pulmonary and renal vasculature: vasoconstriction

Question # 11 (Multiple Answer) (Imitrex) and :

A) relieves symptoms for few patients
B) efficacy greater than or equal to other drug treatments
C) multiple dosing may be required

Question # 12 (Multiple Answer) Serotonin agonists -- use:

A) -- anxiolytic
B) (Imitrex) -- antimigraine; anti-cluster headaches
C) both
D) neither

Question # 13 (Multiple Answer) Serotonin: nervous system --

A) stimulates itch and pain sensory nerve endings
B) activates chemosensitive nerve endings in coronary vessels
C) atropine-sensitive bradycardia
D) activates medullary vomiting reflex (5 HT3)

Question # 14 (Multiple Choice) ondansetron (Zofran), granisetron (Kytril), tropisetron interact with its serotonin receptor subtype located in the area postrema, sensory, and enteric nerves:

A) 5 HT1a
B) 5 HT1d
C) 5 HT3
D) 5 HT4

Question # 15 (Multiple Choice) (Imitrex) -- contraindications

A) presence of ischemic heart disease
B) patients have variant (Prinzmetal's) angina
C) both
D) neither

Question # 16 (Multiple Answer) Ondansetron (Zofran) -- pharmacology:

A) activates dopamine (Intropin), histamine and receptors
B) very effective for prevention of nausea iand vomiting caused by chemotherapy or surgery
C) reduces postoperative vomiting in patients following middle ear surgery

Question # 17 (Multiple Answer) Adverse effects -- sumatriptan (Imitrex)

A) muscle weakness
B) chest pain
C) dizziness
D) altered sensations (tingling, warmth recurrent


--------------------------------------------------------------------------


Correct Answers

hidden content may not be quoted







.

thank you guys