Parkinson's Disease - questions


Question # 1 (Multiple Choice) Reason that dopamine itself is not used to treat in Parkinson's disease:

A) too expensive
B) the problem is cholinergic in nature
C) dopamine does not cross the blood-brain barrier
D) levodopa has a higher affinity for the D2 receptor

Question # 2 (Multiple Choice) Dominantly inherited disease: associated with progressive chorea and dementia; related to neurotransmitter imbalance

A) Wilson's disease
B) tardive dyskinesia
C) Tourette's syndrome
D) Huntington's disease
E) Shy-Drager syndrome

Question # 3 (Multiple Choice) Antiviral drug found to have anti-Parkinson's properties:

A) procyclidine
B) pergolide
C) amantadine
D) levodopa
E) reserpine

Question # 4 (True/False) Benefits of dopaminergicanti--Parkinson's drugs probably due to stimulation of D2 dopamine receptors

A) true
B) false

Question # 5 (Multiple Choice) Irregular, unpredictable, involuntary muscle contractions:

A) athetosis
B) dystonia
C) tics
D) chorea
E) akinesia

Question # 6 (Multiple Choice) Dopamine agonist ergot derivative -- stimulates D1 & D2 receptors

A) levodopa
B) amantadine
C) pergolide
D) selegiline
E) trihexyphenidyl

Question # 7 (Multiple Choice) Characterized by chronic, multiple tics:

A) Parkinson's disease
B) Wilson's disease
C) Shy-Drager syndrome
D) Tourette's syndrome
E) all of the above

Question # 8 (Multiple Choice) Percentage of levodopa that enters the brain unaltered

A) 1-3%
B) 5-10%
C) 15-30%
D) > 50%

Question # 9 (Multiple Answer) Effective in managing essential tremor

A) propranolol
B) metoprolol
C) primidone
D) diazepam
E) chlordiazepoxide

Question # 10 (Multiple Choice) First-line anti-Parkinson drug; also used to treat hyperprolactinemia at lower doses

A) amantadine
B) levodopa
C) bromocriptine
D) selegiline
E) benztropine mesylate

Question # 11 (Multiple Choice) Carbidopa is useful in the management of Parkinson's disease because it is an:

A) effective D2 agonist
B) effective D2 antagonist
C) effective peripheral decarboxylase inhibitor
D) effective central decarboxylase inhibitor
E) :effective competitor at the GABA receptor


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Correct Answers

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Question # 1 (Multiple Choice) Reason that dopamine itself is not used to treat in Parkinson's disease:

Answer: (C) dopamine does not cross the blood-brain barrier



Question # 2 (Multiple Choice) Dominantly inherited disease: associated with progressive chorea and dementia; related to neurotransmitter imbalance

Answer: (D) Huntington's disease


Question # 3 (Multiple Choice) Antiviral drug found to have anti-Parkinson's properties:

Answer: (C) amantadine

Anti-Parkinson mechanism of action unclear; knack by affecting dopamine reuptake, synthesis, or release


Question # 4 (True/False) Benefits of dopaminergicanti--Parkinson's drugs probably due to stimulation of D2 dopamine receptors

Answer: True


Question # 5 (Multiple Choice) Irregular, unpredictable, involuntary muscle contractions:

Answer: (D) chorea

chorea: may be hereditary, secondary to non--neurological disease; drug-induced


Question # 6 (Multiple Choice) Dopamine agonist ergot derivative -- stimulates D1 & D2 receptors

Answer: (C) pergolide

pergolide & bromocriptine are ergot alkaloid derivatives useful in treating Parkinson's disease


Question # 7 (Multiple Choice) Characterized by chronic, multiple tics:

Answer: (D) Tourette's syndrome


Question # 8 (Multiple Choice) Percentage of levodopa that enters the brain unaltered

Answer: (A) 1-3%

most levodopa is metabolized extracerebrally



Question # 9 (Multiple Answer) Effective in managing essential tremor

(A) propranolol


(B) metoprolol


(C) primidone


probably a beta-adrenergic receptor dysfunction; anti-Parkinson agents, diazepam, chlordiazepoxide, mephenesin not useful


Question # 10 (Multiple Choice) First-line anti-Parkinson drug; also used to treat hyperprolactinemia at lower doses

Answer: (C) bromocriptine

ergot derivative; dopamine agonist, probably at D2 receptors



Question # 11 (Multiple Choice) Carbidopa is useful in the management of Parkinson's disease because it is an:

Answer: (C) effective peripheral decarboxylase inhibitor

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