Understanding - Leukemia


Question 1

Important aspects to keep in mind when interpreting an elevated white blood cell count on a CBC is/are

a. quality of the cells.
b. quantity of the cells
c. clinical circumstances
d. all of the above


[HIDE]The correct answer is: d [/HIDE]


Question 2

All of the following are helpful in distinguishing an elevated granulocyte count due to infection (leukemoid reaction) from an elevated granulocyte count of leukemia EXCEPT

a. total WBC count of 45,000
b. high LAP score
c. high vitamin B12 level
d. detection of BCR-ABL gene product in the serum.


[HIDE]The correct answer is: a[/HIDE]

Question 3

When speaking of leukemia, the terms acute and chronic apply to

a. how quickly the initial symptoms developed.
b. the duration of the course of the untreated illness.
c. whether or not bleeding was present at the time of diagnosis
d. none of the above


[HIDE]The correct answer is: b [/HIDE]


Question 4

Because of the unregulated proliferation of the leukemic cells in the bone marrow, one can predict problems with which of the following healthy marrow cell lines?

a. RBC
b. WBC
c. megakaryocytic
d. All of the above

[HIDE]The correct answer is: d [/HIDE]


Question 5

The cytoplasmic feature in the following cell indicates this person has what form of leukemia?


a. Acute lymphocytic
b. Chronic lymphocytic
c. Acute myelocytic
d. Chronic myelocytic


[HIDE]The correct answer is: c [/HIDE]


Question 6

In the case of a myelodysplastic syndrome, the bone marrow cell line that most consistently shows a diagnostic change is

a. the RBC series
b. the WBC series
c. the megakaryocytic line
d. the lymphoid line

[HIDE]The correct answer is: a[/HIDE]

Question 7

In the case of myeloproliferative disorders (which includes chronic myelocytic leukemia), the malignant cell is

a. a primitive granulocyte precursor
b. the ringed sideroblast
c. the prolymphocyte
d. the stem cell


[HIDE]The correct answer is: d [/HIDE]


Question 8

The classic t(9;22) translocation is known to be associated with which leukemia(s)



a. chronic myelogenous
b. acute lymphocytic
c. both
d. neither


[HIDE]The correct answer is: c [/HIDE]


Question 9

After about 3 years of CML, about 50% of patients will develop what is called an accelerated phase of the disease. Peripheral blood findings associated with this phase of the illness include



a. increased numbers of blasts
b. increased basophil count
c. both
d. neither


[HIDE]The correct answer is: c [/HIDE]


Question 10

Some lymphoctic leukemias and lymphomas are identical from a cellular stand point, and differ clinically only with respect to

a. CD marker status
b. T or B cell origin
c. Development of anergy
d. Degree of involvement of the bone marrow and subsequent presence of malignant cells in the circulating blood.

[HIDE]The correct answer is: d [/HIDE]]