PHARMACOLOGY CASE STUDY - 10 Cases
PHARMACOLOGY CASE 1:
Respiratory Distress and Audible Wheezing
A 12-year-old girl presents to your office with a sore throat and fever. You diagnose her with pharyngitis caused by group A .-hemolytic streptococcus. She is given an IM injection of penicillin. Approximately 5 minutes later, she is found to be in respiratory distress and audibly wheezing. Her skin is mottled and cool, she is tachycardic (rapid heart rate), and her blood pressure has fallen to 70/20 mmHg. You immediately diagnose her as having an anaphylactic reaction to the penicillin and give a subcutaneous injection of epinephrine. Case 1 Questions:
• What effect will epinephrine have on this patient’s vascular system?
• Which adrenoceptor primarily mediates the vascular response?
• What effect will epinephrine have on her respiratory system?
• Which adrenoceptor primarily mediates the respiratory system response?
-------------------------- ANSWERS TO CASE 1: Autonomic Sympathetic Nervous System Summary: A 12-year-old girl with “strep throat” is given an injection of penicillin and develops an acute anaphylactic reaction. Effect of epinephrine on vascular system:
Vasoconstriction. Adrenoceptor which primarily mediates the vascular response:
Alpha-1 (a1) . Effect of epinephrine on the pulmonary system:
Bronchial muscle relaxation. Adrenoceptor which primarily mediates the pulmonary response:
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