A 53-year-old Woman Feels A Lump In Her Right Breast. Her Physician Palpates An Irregular 3 Cm Mass That Is Not Movable Because It Appears Fixed To The Overlying Skin, Which Is Retracted. A Mastectomy Is Performed And The Pathologist On Sectioning The Breast Finds A 3 X 3.5 Cm Ovoid Mass That Does Not Have Discrete Borders, But Appears To Infiltrate Into The Surrounding Fibrofatty Breast Stroma. The Mass Is Firm, White, And Has A Fibrous Consistency.

Which Of The Following Features Is Most Likely Demonstrated By The Gross Appearance Of This Mass?

A Anaplasia

B Aplasia

C Desmoplasia

D Dysplasia

E Metaplasia


answer / Explanation:

(c) Correct.

Neoplasms, And Malignant Neoplasms In Particular, Can Form A Fibrous Stroma That Gives The Tumor A Characteristic Firm Or Hard Feel On Palpation. This Connective Tissue Can Fix The Tumor To Surrounding Structures. An Infiltrating Ductal Carcinoma Of The Breast Will Often Have This Appearance.