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Thread: Meningioma arises from ??

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    Thumbs up Meningioma arises from ??

    Meningioma arises from-

    a) Extra dural arteries
    b) Extra cranial muscles
    c) Venous sinuses
    d) Arachnoid cap cells


    [hide]
    The meningioma is the neurosurgeon's "friend" and often his most enduring challenge. For both the physician and patient, this tumor carries a true tag of benign. It also carries the possibility of "cure" in approximately 80% of cases. Thus, the long-term outcome for a patient with this tumor is a direct function of the skill and assiduousness of the surgeon who removes it.

    Elsewhere in the Brain Surgery Information Center's Primer on Brain Tumor Biology, it was mentioned that "benign" often does not really mean benign. Be assured that in this case, the tumor really is benign.

    As mentioned earlier in the Primer, each type of brain tumor arises from a specific cell type. The cell of origin for the meningioma is call the arachnoid cap cell, found on the surface coverings (called meninges) of the brain in the paccionian granulations. These serve as the one-way valve system between the water system of the brain and the veins that drain from the brain to the heart.

    Interestingly, these tumors have an embryologic relationship with cells found in the muscle layer of the utereus icon_eek.gif . In fact, it is exceedingly difficult for the pathologist to distinguish the meningioma from the fibroid tumors of the utereus under the microscope. Also, they share the characteristic female hormonal receptors (estrogen and progesterone) on their cell surfaces.



    [/hide]
    Last edited by Amal; 07-22-2008 at 08:50 PM.

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    More information....


    [hide]
    The following are the main points about optic nerve meningioma:

    orbital and optic nerve sheath meningioma are less common than intracranial meningioma. Orbital meningioma often arises secondarily from either intracranial meningioma or optic nerve sheath meningioma.
    it is commoner in middle-aged female.
    there is a small increased incidence in neurofibromatosis type I
    clinical signs of optic nerve meningioma include unilateral papilloedema, optic atrophy and optico-ciliary shunt
    there are a variety of histological patterns but within the orbit only two are commonly found (see pictures below for description):

    meningotheliomatous



    Meningotheliomatous type of meningioma. This is the most common cell type
    seen in all meningioma. The tumour has large, ill-defined cells with abundant
    cytoplasm. Numerous whorls are formed by several flattened cells wrapped
    around a large round cell. Psammomas bodies sometimes occur within the whorls.

    psammomatous



    This is a variant characterized by the abundance of psammoma bodies.These can
    form confluent masses between which lie islands of meningothelial or fibroblastic
    -like cells. This is seen less commonly than meningotheliomatous type. [/hide]

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