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Thread: dude u gotta help me out

  1. #1
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    Cool dude u gotta help me out

    hey. there was a ques in which our seniors were asked about the drugs contraindicated in pregnancy, trimester wise..
    as in drugs contraindicated in 1st , 2nd and 3rd trimesters individually.. i tried lookinmg up the internet, bt cdnt find ny information.. i looked up a few books, bt cdnt find there either.. so i hope, if any of u guys cud help me out.. m a newbie, nd i seriously need ur help, coz my exms are round the corner..

    i also need the differences in albendazole, and mebendazole..

  2. #2
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    Well, drug which cause congenital malformation are contraindicated specially during 1st trimester as it's the period of organogenesis.

    The categories are A, B, C, D and X. Generally speaking, drugs that fall into either class A or B are considered safe and are routinely used. There may be exceptions.

    Category A: Controlled studies in pregnant women fail to demonstrate a risk to the fetus in the first trimester with no evidence of risk in later trimesters. The possibility of harm appears remote.

    Category B: Presumed safety based on animal studies, with no controlled studies in pregnant women, or animal studies have shown an adverse effect that was not confirmed in controlled studies in women in the first trimester and there is no evidence of a risk in later trimesters.

    Category C: Studies in women and animals are not available or studies in animals have revealed adverse effects on the fetus and there are no controlled studies in women. Drugs should be given only if the potential benefits justify the potential risk to the fetus.

    Category D: There is positive evidence of human fetal risk (unsafe), however in some cases such as a life-threatening illness the potential risk may be justified if there are no other alternatives.

    Category X: Highly unsafe: risk of use outweighs any potential benefit. Drugs in this category are contraindicated in women who are or may become pregnant.

    PDF file:

    Code:
    http://media.haymarketmedia.com/Documents/2/DCIP_2pg_1170.pdf


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