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Thread: Placental Pharmacokinetics

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    Arrow Placental Pharmacokinetics

    Placental Pharmacokinetics

    Table of Contents


    1. Introduction
    2. Review of the literature
    2.1. Drug metabolism
    2.1.1. General aspects of drug metabolism
    2.1.2. Drug-metabolizing enzymes
    2.1.3. Induction and inhibition of drug metabolism
    2.1.4. Human in vitro models for the study of drug metabolism
    2.2. Pharmacokinetics during pregnancy
    2.3. Placental pharmacokinetics of xenobiotics
    2.3.1. Placental anatomy and physiology
    2.3.2. Principles of placental drug transfer
    2.3.3. Placental metabolism of drugs
    2.3.4. Models for the study of placental drug metabolism and transfer
    2.4. In vitro-in vivo correlation of different methods used as models of placental drug transfer and drug metabolism
    2.5. Anticonvulsants and epilepsy
    2.6. Pharmacokinetics of selected anticonvulsants
    2.6.1. Carbamazepine
    2.6.2. Oxcarbazepine
    2.6.3. Lamotrigine
    2.6.4. Diazepam
    3. Aims of the study
    4. Materials and methods
    4.1. Materials
    4.2. Methods to study drug metabolism
    4.3. Methods to study transplacental drug passage
    4.3.1. Samples from mothers on antiepileptic drug therapy
    4.3.2. Placental perfusion system
    4.4. Analysis of drugs
    4.5. Statistical analysis
    4.6. Ethical aspects
    5. Results
    5.1. Metabolism of carbamazepine and oxcarbazepine in liver and placenta
    5.1.1. Carbamazepine metabolism
    5.1.2. Oxcarbazepine metabolism (paper I)
    5.2. Placental perfusion experiments
    5.2.1. Placental perfusion method (papers IV and V)
    5.2.2. Antipyrine (papers IV and V)
    5.2.3. Lamotrigine (paper IV)
    5.2.4. Diazepam (paper V)
    5.3. Clinical samples from maternal serum and cord blood
    5.3.1. Oxcarbazepine (paper III)
    5.3.2. Lamotrigine (paper IV)
    6. Discussion
    6.1. Carbamazepine metabolism in different in vitro systems
    6.2. Oxcarbazepine metabolism in vitro in liver and placenta (paper I)
    6.3. Binding of carbamazepine and oxcarbazepine to macromolecules (paper I)
    6.4. Distribution of lamotrigine and diazepam in placental perfusions (papers IV and V)
    6.5. Placental transfer of anticonvulsants in a perfusion system and in clinical samples (papers III–V)
    ---------================================================== ========


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  2. #2
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    thaaaaaaaaaaaaaaaaaaaanks

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    thank you

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