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Thread: Revising Drug Metabolism

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    Thumbs up Revising Drug Metabolism

    Phase 1 reactions

    Cyclization and decyclization reactions involving cytochrome P450 enzymes
    1.Cytochrome P450 dependent oxidation

    a.hydroxylation
    aromatic compounds-->phenytoin,phenobarbitone
    aliphatic compounds-->digitoxin,ibuprofen

    b.dealkylation
    N- diazepam,caffeine
    O- indomethacin
    S- 6-methyl thiopurine

    c.oxidation
    N- acetaminophen,chlorpheniramine
    S- omeprazole

    d.deamination
    diazepam,amphetamine

    e.desulfuration
    thiopental,parathion

    f.dechlorination
    carbon tetrachloride

    2.Non microsomal or cytochrome P450 independent oxidation

    a.dehydrogenation
    ethyl alcohol

    b.amine oxidases
    epinephrine

    c.flavin mono-oxygenase
    chlorpromazine,amitryptiline

    3.Cytochrome P450 dependent Reduction

    a.azo reduction
    prontosil

    b.nitro reduction
    chloramphenicol,clonazepam

    4.Cytochrome P450 independent hydrolysis


    a.esterases

    procaine,cocaine,aspirin

    b.amidases
    lignocaine,indomethacin

    Phase 2 reactions

    1.Glucoronidation
    diazepam,morphine
    2.acetylation
    sulphonamides
    3.glutathione conjugation
    ethacrynic acid
    4.glycine conjugation
    cholic acid
    5.sulfate conjugation
    estrone,acetaminophen
    6.methylation
    histamine,pyridine
    7.water conjugation
    carbamazpine epoxide

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    Great thng broz!!!!
    thnxs

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