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Thread: Glioblastoma multiforme - Highly malignant Brain Tumor

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    Glioblastoma multiforme - Highly malignant Brain Tumor


    Introduction:

    Also called spongioblastoma multiforme, this form of brain tumor is the most common form of gliomas. It affects mostly adults (peak age 50 to 60 years) and is twice as common in men.

    Glioblastoma accounts for 30 percent of all brain tumors, and is the most common primary brain tumor of adults. Glioblastomas occur most often in older adults, both men and women. Less than 10 percent of childhood brain tumors are glioblastomas.

    Glioblastoma multiforme is a highly malignant tumor that grows rapidly and infiltrates the brain extensively. It may become quite large before it is diagnosed.

    This form of tumor is usually found in the cerebral hemispheres, particularly the frontal and temporal lobe. It may traverse the corpus callosum to the opposite hemisphere, and can metastasize to infect other tissues of the nervous system through the cerebrospinal fluid.

    The symptoms of glioblastoma multiforme include:

    Increased ICP
    Nausea
    Vomiting, particularly in children
    Headache
    Papilledema or accumulation of fluid in the optic disc of the eye
    Changes in vital signs, including increased blood pressure and breathing changes
    Difficulty in speech
    Changes in mental ability and behavior, particularly irritability in children
    Changes in senses


    Depending on the location of the tumor, glioblastoma multiforme may also have the following symptoms:


    Location: Midline---Symptoms:Headache that is worse in the morning and made worse by coughing, straining or sudden head movements

    Location: Temporal Lobe---Symptoms: Seizure

    Location: Central region---Symptoms:Partial or focal seizure

    Location: Optic and oculomotor nervesSymptoms: Visual acuity changes, visual problems

    Location: Frontal lobe---Symptoms: Changes in reflex and motor responses


    How do I know if I have a glioblastoma?

    Your specialist will conduct a neurological examination, followed by CT scans and/or an MRI. This will help determine the size, location and type of tumor. The diagnosis can be confirmed by a biopsy.

    What treatments are available?

    There are many options for treating glioblastomas:

    Image-guided neurosurgery
    Interventional MRI
    High-precision radiosurgery, including three-dimensional conformal radiotherapy and stereotactic radiosurgery
    Interstitial brachytherapy (radiation seed implants)
    Chemotherapy



    In-depth details:

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    Last edited by trimurtulu; 12-08-2008 at 07:13 PM.

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