Ostrosky-Zeichner Clinical prediction rule for ICU acquired candidemia
  • Mechanical ventilation > 48 hr
  • Any systemic antibiotic
  • Central line
  • TPN
  • RRT
  • Any major surgery
  • Pancreatitis
  • Steroid
Original Rule(2007)

Any systemic antibiotic (days 1-3) OR presence of a central venous catheter (days 1-3)

AND at least TWO of the following

total parenteral nutrition (days 1-3),
any dialysis (days 1-3),
any major surgery (days -7-0),
pancreatitis (days -7-0),
any use of steroids (days -7-3), or use of other immunosuppressive agents (days -7-0).
Modified Rule (2011)

Have been mechanically ventilated
for at least 48 h
Antibacterial antibiotic use, D 13
CVC, D 13

AND at least one of the following

additional risk factors:

Any surgery, D 70
Immunosuppressive use, D 70

Pancreatitis, D 70
TPN, D 13
Any dialysis, D 13
Steroid use, D 70

Reference :

Ostrosky-Zeichner et. al. Mycoses. 2011 Jan;54(1):46-51

2007 : Multicenter retrospective development and validation of a clinical prediction rule for nosocomial invasive candidiasis in the intensive care setting.
2011 : Improvement of a clinical prediction rule for clinical trials on prophylaxis for invasive candidiasis in the intensive care unit.