Case Study:

A 32-year-old G2 P1 woman has an uncomplicated vaginal delivery of a 30 week gestational age male infant. Apgar scores of 5 and 7 at 1 minute and 5 minutes are recorded at the time of birth. The baby then begins to exhibit increasing respiratory difficulty in the next hour, culminating in the need for intubation and mechanical ventilation.

Which of the following laboratory tests during gestation is most likely to predict the complication observed in this infant?


A Maternal serum alpha fetoprotein

B Chromosome analysis on fetal cells from amniocentesis

C Fluorescence polarization (fpol) on amniotic fluid

D TORCH titers on maternal blood

E Maternal cocaine screen on blood and urine

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Answer / Explanation:

[HIDE]

(C) CORRECT.

There is fetal lung immaturity leading to hyaline membrane disease. Tests for fetal lung maturity (usually reached by 35 to 36 weeks), including L:S ratio, phosphatidylglycerol, and fluorescence polarization (fpol) can be done on amniotic fluid.[/HIDE]